The Global Phosphorylation Landscape of SARS-CoV-2 Infection.
Identifieur interne : 000468 ( Main/Exploration ); précédent : 000467; suivant : 000469The Global Phosphorylation Landscape of SARS-CoV-2 Infection.
Auteurs : Mehdi Bouhaddou [États-Unis] ; Danish Memon [Royaume-Uni] ; Bjoern Meyer [France] ; Kris M. White [États-Unis] ; Veronica V. Rezelj [France] ; Miguel Correa Marrero [Royaume-Uni] ; Benjamin J. Polacco [États-Unis] ; James E. Melnyk ; Svenja Ulferts [Allemagne] ; Robyn M. Kaake [États-Unis] ; Jyoti Batra [États-Unis] ; Alicia L. Richards [États-Unis] ; Erica Stevenson [États-Unis] ; David E. Gordon [États-Unis] ; Ajda Rojc [États-Unis] ; Kirsten Obernier [États-Unis] ; Jacqueline M. Fabius [États-Unis] ; Margaret Soucheray [États-Unis] ; Lisa Miorin [États-Unis] ; Elena Moreno [États-Unis] ; Cassandra Koh [France] ; Quang Dinh Tran [France] ; Alexandra Hardy [France] ; Rémy Robinot [France] ; Thomas Vallet [France] ; Benjamin E. Nilsson-Payant [États-Unis] ; Claudia Hernandez-Armenta [Royaume-Uni] ; Alistair Dunham [Royaume-Uni] ; Sebastian Weigang [Allemagne] ; Julian Knerr [Allemagne] ; Maya Modak [États-Unis] ; Diego Quintero [États-Unis] ; Yuan Zhou [États-Unis] ; Aurelien Dugourd [Allemagne] ; Alberto Valdeolivas [Allemagne] ; Trupti Patil [États-Unis] ; Qiongyu Li [États-Unis] ; Ruth Hüttenhain [États-Unis] ; Merve Cakir [États-Unis] ; Monita Muralidharan [États-Unis] ; Minkyu Kim [États-Unis] ; Gwendolyn Jang [États-Unis] ; Beril Tutuncuoglu [États-Unis] ; Joseph Hiatt [États-Unis] ; Jeffrey Z. Guo [États-Unis] ; Jiewei Xu [États-Unis] ; Sophia Bouhaddou [États-Unis] ; Christopher J P. Mathy [États-Unis] ; Anna Gaulton [Royaume-Uni] ; Emma J. Manners [Royaume-Uni] ; Eloy Félix [Royaume-Uni] ; Ying Shi ; Marisa Goff [États-Unis] ; Jean K. Lim [États-Unis] ; Timothy Mcbride [États-Unis] ; Michael C. O'Neal [États-Unis] ; Yiming Cai [États-Unis] ; Jason C J. Chang [États-Unis] ; David J. Broadhurst [États-Unis] ; Saker Klippsten [États-Unis] ; Emmie De Wit [États-Unis] ; Andrew R. Leach [Royaume-Uni] ; Tanja Kortemme [États-Unis] ; Brian Shoichet [États-Unis] ; Melanie Ott [États-Unis] ; Julio Saez-Rodriguez [Allemagne] ; Benjamin R. Tenoever [États-Unis] ; R Dyche Mullins ; Elizabeth R. Fischer [États-Unis] ; Georg Kochs [Allemagne] ; Robert Grosse [Allemagne] ; Adolfo García-Sastre [États-Unis] ; Marco Vignuzzi [France] ; Jeffery R. Johnson [États-Unis] ; Kevan M. Shokat [États-Unis] ; Danielle L. Swaney [États-Unis] ; Pedro Beltrao [Royaume-Uni] ; Nevan J. Krogan [États-Unis]Source :
- Cell [ 1097-4172 ] ; 2020.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Antiviraux (pharmacologie), Betacoronavirus (métabolisme), Casein Kinase II (antagonistes et inhibiteurs), Casein Kinase II (métabolisme), Cellules A549 (MeSH), Cellules Caco-2 (MeSH), Cellules HEK293 (MeSH), Cellules Vero (MeSH), Glycoprotéine de spicule des coronavirus (métabolisme), Humains (MeSH), Infections à coronavirus (métabolisme), Infections à coronavirus (virologie), Inhibiteurs de protéines kinases (pharmacologie), Interactions hôte-pathogène (MeSH), Kinases cyclines-dépendantes (antagonistes et inhibiteurs), Kinases cyclines-dépendantes (métabolisme), Pandémies (MeSH), Peptidyl-Dipeptidase A (génétique), Peptidyl-Dipeptidase A (métabolisme), Phosphatidylinositol 3-kinases (métabolisme), Phosphorylation (MeSH), Pneumopathie virale (métabolisme), Pneumopathie virale (virologie), Protéines proto-oncogènes (antagonistes et inhibiteurs), Protéines proto-oncogènes (métabolisme), Protéomique (méthodes), Récepteurs à activité tyrosine kinase (antagonistes et inhibiteurs), Récepteurs à activité tyrosine kinase (métabolisme), p38 Mitogen-Activated Protein Kinases (antagonistes et inhibiteurs), p38 Mitogen-Activated Protein Kinases (métabolisme), Évaluation préclinique de médicament (méthodes).
- MESH :
- antagonistes et inhibiteurs : Casein Kinase II, Kinases cyclines-dépendantes, Protéines proto-oncogènes, Récepteurs à activité tyrosine kinase, p38 Mitogen-Activated Protein Kinases.
- génétique : Peptidyl-Dipeptidase A.
- métabolisme : Betacoronavirus, Casein Kinase II, Glycoprotéine de spicule des coronavirus, Infections à coronavirus, Kinases cyclines-dépendantes, Peptidyl-Dipeptidase A, Phosphatidylinositol 3-kinases, Pneumopathie virale, Protéines proto-oncogènes, Récepteurs à activité tyrosine kinase, p38 Mitogen-Activated Protein Kinases.
- méthodes : Protéomique, Évaluation préclinique de médicament.
- pharmacologie : Antiviraux, Inhibiteurs de protéines kinases.
- virologie : Infections à coronavirus, Pneumopathie virale.
- Animaux, Cellules A549, Cellules Caco-2, Cellules HEK293, Cellules Vero, Humains, Interactions hôte-pathogène, Pandémies, Phosphorylation.
English descriptors
- KwdEn :
- A549 Cells (MeSH), Animals (MeSH), Antiviral Agents (pharmacology), Betacoronavirus (metabolism), Caco-2 Cells (MeSH), Casein Kinase II (antagonists & inhibitors), Casein Kinase II (metabolism), Chlorocebus aethiops (MeSH), Coronavirus Infections (metabolism), Coronavirus Infections (virology), Cyclin-Dependent Kinases (antagonists & inhibitors), Cyclin-Dependent Kinases (metabolism), Drug Evaluation, Preclinical (methods), HEK293 Cells (MeSH), Host-Pathogen Interactions (MeSH), Humans (MeSH), Pandemics (MeSH), Peptidyl-Dipeptidase A (genetics), Peptidyl-Dipeptidase A (metabolism), Phosphatidylinositol 3-Kinases (metabolism), Phosphoinositide-3 Kinase Inhibitors (pharmacology), Phosphorylation (MeSH), Pneumonia, Viral (metabolism), Pneumonia, Viral (virology), Protein Kinase Inhibitors (pharmacology), Proteomics (methods), Proto-Oncogene Proteins (antagonists & inhibitors), Proto-Oncogene Proteins (metabolism), Receptor Protein-Tyrosine Kinases (antagonists & inhibitors), Receptor Protein-Tyrosine Kinases (metabolism), Spike Glycoprotein, Coronavirus (metabolism), Vero Cells (MeSH), p38 Mitogen-Activated Protein Kinases (antagonists & inhibitors), p38 Mitogen-Activated Protein Kinases (metabolism).
- MESH :
- chemical , antagonists & inhibitors : Casein Kinase II, Cyclin-Dependent Kinases, Proto-Oncogene Proteins, Receptor Protein-Tyrosine Kinases, p38 Mitogen-Activated Protein Kinases.
- chemical , genetics : Peptidyl-Dipeptidase A.
- chemical , metabolism : Casein Kinase II, Cyclin-Dependent Kinases, Peptidyl-Dipeptidase A, Proto-Oncogene Proteins, Receptor Protein-Tyrosine Kinases, Spike Glycoprotein, Coronavirus, p38 Mitogen-Activated Protein Kinases.
- chemical , pharmacology : Antiviral Agents, Phosphoinositide-3 Kinase Inhibitors, Protein Kinase Inhibitors.
- metabolism : Betacoronavirus, Coronavirus Infections, Phosphatidylinositol 3-Kinases, Pneumonia, Viral.
- methods : Drug Evaluation, Preclinical, Proteomics.
- virology : Coronavirus Infections, Pneumonia, Viral.
- A549 Cells, Animals, Caco-2 Cells, Chlorocebus aethiops, HEK293 Cells, Host-Pathogen Interactions, Humans, Pandemics, Phosphorylation, Vero Cells.
Abstract
The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed hundreds of thousands of people worldwide, highlighting an urgent need to develop antiviral therapies. Here we present a quantitative mass spectrometry-based phosphoproteomics survey of SARS-CoV-2 infection in Vero E6 cells, revealing dramatic rewiring of phosphorylation on host and viral proteins. SARS-CoV-2 infection promoted casein kinase II (CK2) and p38 MAPK activation, production of diverse cytokines, and shutdown of mitotic kinases, resulting in cell cycle arrest. Infection also stimulated a marked induction of CK2-containing filopodial protrusions possessing budding viral particles. Eighty-seven drugs and compounds were identified by mapping global phosphorylation profiles to dysregulated kinases and pathways. We found pharmacologic inhibition of the p38, CK2, CDK, AXL, and PIKFYVE kinases to possess antiviral efficacy, representing potential COVID-19 therapies.
DOI: 10.1016/j.cell.2020.06.034
PubMed: 32645325
PubMed Central: PMC7321036
Affiliations:
- Allemagne, France, Royaume-Uni, États-Unis
- Bade-Wurtemberg, Californie, District de Fribourg-en-Brisgau, District de Karlsruhe, Montana, État de New York, Île-de-France
- Créteil, Fribourg-en-Brisgau, Heidelberg
Links toward previous steps (curation, corpus...)
Le document en format XML
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White</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029</wicri:regionArea><wicri:noRegion>10029</wicri:noRegion></affiliation></author><author><name sortKey="Rezelj, Veronica V" sort="Rezelj, Veronica V" uniqKey="Rezelj V" first="Veronica V" last="Rezelj">Veronica V. 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Polacco</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Melnyk, James E" sort="Melnyk, James E" uniqKey="Melnyk J" first="James E" last="Melnyk">James E. Melnyk</name><affiliation><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute.</nlm:affiliation><wicri:noCountry code="subField">USA; Howard Hughes Medical Institute</wicri:noCountry></affiliation></author><author><name sortKey="Ulferts, Svenja" sort="Ulferts, Svenja" uniqKey="Ulferts S" first="Svenja" last="Ulferts">Svenja Ulferts</name><affiliation wicri:level="3"><nlm:affiliation>Institute for Clinical and Experimental Pharmacology and Toxicology, University of Freiburg, Freiburg 79104, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Clinical and Experimental Pharmacology and Toxicology, University of Freiburg, Freiburg 79104</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Kaake, Robyn M" sort="Kaake, Robyn M" uniqKey="Kaake R" first="Robyn M" last="Kaake">Robyn M. 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David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Batra, Jyoti" sort="Batra, Jyoti" uniqKey="Batra J" first="Jyoti" last="Batra">Jyoti Batra</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Richards, Alicia L" sort="Richards, Alicia L" uniqKey="Richards A" first="Alicia L" last="Richards">Alicia L. Richards</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Stevenson, Erica" sort="Stevenson, Erica" uniqKey="Stevenson E" first="Erica" last="Stevenson">Erica Stevenson</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Gordon, David E" sort="Gordon, David E" uniqKey="Gordon D" first="David E" last="Gordon">David E. Gordon</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rojc, Ajda" sort="Rojc, Ajda" uniqKey="Rojc A" first="Ajda" last="Rojc">Ajda Rojc</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Obernier, Kirsten" sort="Obernier, Kirsten" uniqKey="Obernier K" first="Kirsten" last="Obernier">Kirsten Obernier</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Fabius, Jacqueline M" sort="Fabius, Jacqueline M" uniqKey="Fabius J" first="Jacqueline M" last="Fabius">Jacqueline M. Fabius</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Soucheray, Margaret" sort="Soucheray, Margaret" uniqKey="Soucheray M" first="Margaret" last="Soucheray">Margaret Soucheray</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Miorin, Lisa" sort="Miorin, Lisa" uniqKey="Miorin L" first="Lisa" last="Miorin">Lisa Miorin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029</wicri:regionArea><wicri:noRegion>10029</wicri:noRegion></affiliation></author><author><name sortKey="Moreno, Elena" sort="Moreno, Elena" uniqKey="Moreno E" first="Elena" last="Moreno">Elena Moreno</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029</wicri:regionArea><wicri:noRegion>10029</wicri:noRegion></affiliation></author><author><name sortKey="Koh, Cassandra" sort="Koh, Cassandra" uniqKey="Koh C" first="Cassandra" last="Koh">Cassandra Koh</name><affiliation wicri:level="1"><nlm:affiliation>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15</wicri:regionArea><wicri:noRegion>Cedex 15</wicri:noRegion><wicri:noRegion>Cedex 15</wicri:noRegion></affiliation></author><author><name sortKey="Tran, Quang Dinh" sort="Tran, Quang Dinh" uniqKey="Tran Q" first="Quang Dinh" last="Tran">Quang Dinh Tran</name><affiliation wicri:level="1"><nlm:affiliation>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15</wicri:regionArea><wicri:noRegion>Cedex 15</wicri:noRegion><wicri:noRegion>Cedex 15</wicri:noRegion></affiliation></author><author><name sortKey="Hardy, Alexandra" sort="Hardy, Alexandra" uniqKey="Hardy A" first="Alexandra" last="Hardy">Alexandra Hardy</name><affiliation wicri:level="1"><nlm:affiliation>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15</wicri:regionArea><wicri:noRegion>Cedex 15</wicri:noRegion><wicri:noRegion>Cedex 15</wicri:noRegion></affiliation></author><author><name sortKey="Robinot, Remy" sort="Robinot, Remy" uniqKey="Robinot R" first="Rémy" last="Robinot">Rémy Robinot</name><affiliation wicri:level="3"><nlm:affiliation>Virus & Immunity Unit, Department of Virology, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France; Vaccine Research Institute, 94000 Creteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Virus & Immunity Unit, Department of Virology, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France; Vaccine Research Institute, 94000 Creteil</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Vallet, Thomas" sort="Vallet, Thomas" uniqKey="Vallet T" first="Thomas" last="Vallet">Thomas Vallet</name><affiliation wicri:level="1"><nlm:affiliation>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15</wicri:regionArea><wicri:noRegion>Cedex 15</wicri:noRegion><wicri:noRegion>Cedex 15</wicri:noRegion></affiliation></author><author><name sortKey="Nilsson Payant, Benjamin E" sort="Nilsson Payant, Benjamin E" uniqKey="Nilsson Payant B" first="Benjamin E" last="Nilsson-Payant">Benjamin E. Nilsson-Payant</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Hernandez Armenta, Claudia" sort="Hernandez Armenta, Claudia" uniqKey="Hernandez Armenta C" first="Claudia" last="Hernandez-Armenta">Claudia Hernandez-Armenta</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Dunham, Alistair" sort="Dunham, Alistair" uniqKey="Dunham A" first="Alistair" last="Dunham">Alistair Dunham</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Weigang, Sebastian" sort="Weigang, Sebastian" uniqKey="Weigang S" first="Sebastian" last="Weigang">Sebastian Weigang</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Virology, Medical Center - University of Freiburg, Freiburg 79104, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, Medical Center - University of Freiburg, Freiburg 79104</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Knerr, Julian" sort="Knerr, Julian" uniqKey="Knerr J" first="Julian" last="Knerr">Julian Knerr</name><affiliation wicri:level="3"><nlm:affiliation>Institute for Clinical and Experimental Pharmacology and Toxicology, University of Freiburg, Freiburg 79104, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Clinical and Experimental Pharmacology and Toxicology, University of Freiburg, Freiburg 79104</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Modak, Maya" sort="Modak, Maya" uniqKey="Modak M" first="Maya" last="Modak">Maya Modak</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Quintero, Diego" sort="Quintero, Diego" uniqKey="Quintero D" first="Diego" last="Quintero">Diego Quintero</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Zhou, Yuan" sort="Zhou, Yuan" uniqKey="Zhou Y" first="Yuan" last="Zhou">Yuan Zhou</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Dugourd, Aurelien" sort="Dugourd, Aurelien" uniqKey="Dugourd A" first="Aurelien" last="Dugourd">Aurelien Dugourd</name><affiliation wicri:level="3"><nlm:affiliation>Institute for Computational Biomedicine, Bioquant, Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Heidelberg 69120, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Computational Biomedicine, Bioquant, Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Heidelberg 69120</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Valdeolivas, Alberto" sort="Valdeolivas, Alberto" uniqKey="Valdeolivas A" first="Alberto" last="Valdeolivas">Alberto Valdeolivas</name><affiliation wicri:level="3"><nlm:affiliation>Institute for Computational Biomedicine, Bioquant, Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Heidelberg 69120, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Computational Biomedicine, Bioquant, Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Heidelberg 69120</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Patil, Trupti" sort="Patil, Trupti" uniqKey="Patil T" first="Trupti" last="Patil">Trupti Patil</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Li, Qiongyu" sort="Li, Qiongyu" uniqKey="Li Q" first="Qiongyu" last="Li">Qiongyu Li</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Huttenhain, Ruth" sort="Huttenhain, Ruth" uniqKey="Huttenhain R" first="Ruth" last="Hüttenhain">Ruth Hüttenhain</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Cakir, Merve" sort="Cakir, Merve" uniqKey="Cakir M" first="Merve" last="Cakir">Merve Cakir</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Muralidharan, Monita" sort="Muralidharan, Monita" uniqKey="Muralidharan M" first="Monita" last="Muralidharan">Monita Muralidharan</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Kim, Minkyu" sort="Kim, Minkyu" uniqKey="Kim M" first="Minkyu" last="Kim">Minkyu Kim</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Jang, Gwendolyn" sort="Jang, Gwendolyn" uniqKey="Jang G" first="Gwendolyn" last="Jang">Gwendolyn Jang</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Tutuncuoglu, Beril" sort="Tutuncuoglu, Beril" uniqKey="Tutuncuoglu B" first="Beril" last="Tutuncuoglu">Beril Tutuncuoglu</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hiatt, Joseph" sort="Hiatt, Joseph" uniqKey="Hiatt J" first="Joseph" last="Hiatt">Joseph Hiatt</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Guo, Jeffrey Z" sort="Guo, Jeffrey Z" uniqKey="Guo J" first="Jeffrey Z" last="Guo">Jeffrey Z. Guo</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Xu, Jiewei" sort="Xu, Jiewei" uniqKey="Xu J" first="Jiewei" last="Xu">Jiewei Xu</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Bouhaddou, Sophia" sort="Bouhaddou, Sophia" uniqKey="Bouhaddou S" first="Sophia" last="Bouhaddou">Sophia Bouhaddou</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Mathy, Christopher J P" sort="Mathy, Christopher J P" uniqKey="Mathy C" first="Christopher J P" last="Mathy">Christopher J P. Mathy</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Gaulton, Anna" sort="Gaulton, Anna" uniqKey="Gaulton A" first="Anna" last="Gaulton">Anna Gaulton</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Manners, Emma J" sort="Manners, Emma J" uniqKey="Manners E" first="Emma J" last="Manners">Emma J. Manners</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Felix, Eloy" sort="Felix, Eloy" uniqKey="Felix E" first="Eloy" last="Félix">Eloy Félix</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Shi, Ying" sort="Shi, Ying" uniqKey="Shi Y" first="Ying" last="Shi">Ying Shi</name><affiliation><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute.</nlm:affiliation><wicri:noCountry code="subField">USA; Howard Hughes Medical Institute</wicri:noCountry></affiliation></author><author><name sortKey="Goff, Marisa" sort="Goff, Marisa" uniqKey="Goff M" first="Marisa" last="Goff">Marisa Goff</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Lim, Jean K" sort="Lim, Jean K" uniqKey="Lim J" first="Jean K" last="Lim">Jean K. Lim</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Mcbride, Timothy" sort="Mcbride, Timothy" uniqKey="Mcbride T" first="Timothy" last="Mcbride">Timothy Mcbride</name><affiliation wicri:level="2"><nlm:affiliation>Zoic Labs, Culver City, CA 90232, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Zoic Labs, Culver City, CA 90232</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="O Neal, Michael C" sort="O Neal, Michael C" uniqKey="O Neal M" first="Michael C" last="O'Neal">Michael C. O'Neal</name><affiliation wicri:level="2"><nlm:affiliation>Zoic Labs, Culver City, CA 90232, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Zoic Labs, Culver City, CA 90232</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Cai, Yiming" sort="Cai, Yiming" uniqKey="Cai Y" first="Yiming" last="Cai">Yiming Cai</name><affiliation wicri:level="2"><nlm:affiliation>Zoic Labs, Culver City, CA 90232, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Zoic Labs, Culver City, CA 90232</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Chang, Jason C J" sort="Chang, Jason C J" uniqKey="Chang J" first="Jason C J" last="Chang">Jason C J. Chang</name><affiliation wicri:level="2"><nlm:affiliation>Zoic Labs, Culver City, CA 90232, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Zoic Labs, Culver City, CA 90232</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Broadhurst, David J" sort="Broadhurst, David J" uniqKey="Broadhurst D" first="David J" last="Broadhurst">David J. Broadhurst</name><affiliation wicri:level="2"><nlm:affiliation>Zoic Labs, Culver City, CA 90232, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Zoic Labs, Culver City, CA 90232</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Klippsten, Saker" sort="Klippsten, Saker" uniqKey="Klippsten S" first="Saker" last="Klippsten">Saker Klippsten</name><affiliation wicri:level="2"><nlm:affiliation>Zoic Labs, Culver City, CA 90232, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Zoic Labs, Culver City, CA 90232</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="De Wit, Emmie" sort="De Wit, Emmie" uniqKey="De Wit E" first="Emmie" last="De Wit">Emmie De Wit</name><affiliation wicri:level="2"><nlm:affiliation>NIH/NIAID/Rocky Mountain Laboratories, Hamilton, MT 59840, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>NIH/NIAID/Rocky Mountain Laboratories, Hamilton, MT 59840</wicri:regionArea><placeName><region type="state">Montana</region></placeName></affiliation></author><author><name sortKey="Leach, Andrew R" sort="Leach, Andrew R" uniqKey="Leach A" first="Andrew R" last="Leach">Andrew R. Leach</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Kortemme, Tanja" sort="Kortemme, Tanja" uniqKey="Kortemme T" first="Tanja" last="Kortemme">Tanja Kortemme</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Shoichet, Brian" sort="Shoichet, Brian" uniqKey="Shoichet B" first="Brian" last="Shoichet">Brian Shoichet</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Ott, Melanie" sort="Ott, Melanie" uniqKey="Ott M" first="Melanie" last="Ott">Melanie Ott</name><affiliation wicri:level="2"><nlm:affiliation>J. David Gladstone Institutes, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>J. David Gladstone Institutes, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Saez Rodriguez, Julio" sort="Saez Rodriguez, Julio" uniqKey="Saez Rodriguez J" first="Julio" last="Saez-Rodriguez">Julio Saez-Rodriguez</name><affiliation wicri:level="3"><nlm:affiliation>Institute for Computational Biomedicine, Bioquant, Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Heidelberg 69120, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Computational Biomedicine, Bioquant, Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Heidelberg 69120</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Tenoever, Benjamin R" sort="Tenoever, Benjamin R" uniqKey="Tenoever B" first="Benjamin R" last="Tenoever">Benjamin R. Tenoever</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Mullins, R Dyche" sort="Mullins, R Dyche" uniqKey="Mullins R" first="R Dyche" last="Mullins">R Dyche Mullins</name><affiliation><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute.</nlm:affiliation><wicri:noCountry code="subField">USA; Howard Hughes Medical Institute</wicri:noCountry></affiliation></author><author><name sortKey="Fischer, Elizabeth R" sort="Fischer, Elizabeth R" uniqKey="Fischer E" first="Elizabeth R" last="Fischer">Elizabeth R. Fischer</name><affiliation wicri:level="2"><nlm:affiliation>NIH/NIAID/Rocky Mountain Laboratories, Hamilton, MT 59840, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>NIH/NIAID/Rocky Mountain Laboratories, Hamilton, MT 59840</wicri:regionArea><placeName><region type="state">Montana</region></placeName></affiliation></author><author><name sortKey="Kochs, Georg" sort="Kochs, Georg" uniqKey="Kochs G" first="Georg" last="Kochs">Georg Kochs</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Virology, Medical Center - University of Freiburg, Freiburg 79104, Germany; Faculty of Medicine, University of Freiburg, Freiburg 79008, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, Medical Center - University of Freiburg, Freiburg 79104, Germany; Faculty of Medicine, University of Freiburg, Freiburg 79008</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Grosse, Robert" sort="Grosse, Robert" uniqKey="Grosse R" first="Robert" last="Grosse">Robert Grosse</name><affiliation wicri:level="3"><nlm:affiliation>Institute for Clinical and Experimental Pharmacology and Toxicology, University of Freiburg, Freiburg 79104, Germany; Faculty of Medicine, University of Freiburg, Freiburg 79008, Germany; Centre for Integrative Biological Signalling Studies (CIBSS), Freiburg 79104, Germany. Electronic address: robert.grosse@pharmakol.uni-freiburg.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Clinical and Experimental Pharmacology and Toxicology, University of Freiburg, Freiburg 79104, Germany; Faculty of Medicine, University of Freiburg, Freiburg 79008, Germany; Centre for Integrative Biological Signalling Studies (CIBSS), Freiburg 79104</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="García-Sastre">Adolfo García-Sastre</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. Electronic address: adolfo.garcia-sastre@mssm.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029</wicri:regionArea><wicri:noRegion>10029</wicri:noRegion></affiliation></author><author><name sortKey="Vignuzzi, Marco" sort="Vignuzzi, Marco" uniqKey="Vignuzzi M" first="Marco" last="Vignuzzi">Marco Vignuzzi</name><affiliation wicri:level="1"><nlm:affiliation>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France. Electronic address: marco.vignuzzi@pasteur.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15</wicri:regionArea><wicri:noRegion>Cedex 15</wicri:noRegion><wicri:noRegion>Cedex 15</wicri:noRegion></affiliation></author><author><name sortKey="Johnson, Jeffery R" sort="Johnson, Jeffery R" uniqKey="Johnson J" first="Jeffery R" last="Johnson">Jeffery R. Johnson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: jeffrey.johnson@mssm.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Shokat, Kevan M" sort="Shokat, Kevan M" uniqKey="Shokat K" first="Kevan M" last="Shokat">Kevan M. Shokat</name><affiliation wicri:level="1"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute. Electronic address: kevan.shokat@ucsf.edu.</nlm:affiliation><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Swaney, Danielle L" sort="Swaney, Danielle L" uniqKey="Swaney D" first="Danielle L" last="Swaney">Danielle L. Swaney</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: danielle.swaney@ucsf.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Beltrao, Pedro" sort="Beltrao, Pedro" uniqKey="Beltrao P" first="Pedro" last="Beltrao">Pedro Beltrao</name><affiliation wicri:level="1"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK. Electronic address: pbeltrao@ebi.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Krogan, Nevan J" sort="Krogan, Nevan J" uniqKey="Krogan N" first="Nevan J" last="Krogan">Nevan J. Krogan</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: nevan.krogan@ucsf.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32645325</idno><idno type="pmid">32645325</idno><idno type="doi">10.1016/j.cell.2020.06.034</idno><idno type="pmc">PMC7321036</idno><idno type="wicri:Area/Main/Corpus">000A45</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000A45</idno><idno type="wicri:Area/Main/Curation">000A45</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000A45</idno><idno type="wicri:Area/Main/Exploration">000A45</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The Global Phosphorylation Landscape of SARS-CoV-2 Infection.</title><author><name sortKey="Bouhaddou, Mehdi" sort="Bouhaddou, Mehdi" uniqKey="Bouhaddou M" first="Mehdi" last="Bouhaddou">Mehdi Bouhaddou</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Memon, Danish" sort="Memon, Danish" uniqKey="Memon D" first="Danish" last="Memon">Danish Memon</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Meyer, Bjoern" sort="Meyer, Bjoern" uniqKey="Meyer B" first="Bjoern" last="Meyer">Bjoern Meyer</name><affiliation wicri:level="1"><nlm:affiliation>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15</wicri:regionArea><wicri:noRegion>Cedex 15</wicri:noRegion><wicri:noRegion>Cedex 15</wicri:noRegion></affiliation></author><author><name sortKey="White, Kris M" sort="White, Kris M" uniqKey="White K" first="Kris M" last="White">Kris M. White</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029</wicri:regionArea><wicri:noRegion>10029</wicri:noRegion></affiliation></author><author><name sortKey="Rezelj, Veronica V" sort="Rezelj, Veronica V" uniqKey="Rezelj V" first="Veronica V" last="Rezelj">Veronica V. Rezelj</name><affiliation wicri:level="1"><nlm:affiliation>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15</wicri:regionArea><wicri:noRegion>Cedex 15</wicri:noRegion><wicri:noRegion>Cedex 15</wicri:noRegion></affiliation></author><author><name sortKey="Correa Marrero, Miguel" sort="Correa Marrero, Miguel" uniqKey="Correa Marrero M" first="Miguel" last="Correa Marrero">Miguel Correa Marrero</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Polacco, Benjamin J" sort="Polacco, Benjamin J" uniqKey="Polacco B" first="Benjamin J" last="Polacco">Benjamin J. Polacco</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Melnyk, James E" sort="Melnyk, James E" uniqKey="Melnyk J" first="James E" last="Melnyk">James E. Melnyk</name><affiliation><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute.</nlm:affiliation><wicri:noCountry code="subField">USA; Howard Hughes Medical Institute</wicri:noCountry></affiliation></author><author><name sortKey="Ulferts, Svenja" sort="Ulferts, Svenja" uniqKey="Ulferts S" first="Svenja" last="Ulferts">Svenja Ulferts</name><affiliation wicri:level="3"><nlm:affiliation>Institute for Clinical and Experimental Pharmacology and Toxicology, University of Freiburg, Freiburg 79104, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Clinical and Experimental Pharmacology and Toxicology, University of Freiburg, Freiburg 79104</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Kaake, Robyn M" sort="Kaake, Robyn M" uniqKey="Kaake R" first="Robyn M" last="Kaake">Robyn M. Kaake</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Batra, Jyoti" sort="Batra, Jyoti" uniqKey="Batra J" first="Jyoti" last="Batra">Jyoti Batra</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Richards, Alicia L" sort="Richards, Alicia L" uniqKey="Richards A" first="Alicia L" last="Richards">Alicia L. Richards</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Stevenson, Erica" sort="Stevenson, Erica" uniqKey="Stevenson E" first="Erica" last="Stevenson">Erica Stevenson</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Gordon, David E" sort="Gordon, David E" uniqKey="Gordon D" first="David E" last="Gordon">David E. Gordon</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rojc, Ajda" sort="Rojc, Ajda" uniqKey="Rojc A" first="Ajda" last="Rojc">Ajda Rojc</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Obernier, Kirsten" sort="Obernier, Kirsten" uniqKey="Obernier K" first="Kirsten" last="Obernier">Kirsten Obernier</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Fabius, Jacqueline M" sort="Fabius, Jacqueline M" uniqKey="Fabius J" first="Jacqueline M" last="Fabius">Jacqueline M. Fabius</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Soucheray, Margaret" sort="Soucheray, Margaret" uniqKey="Soucheray M" first="Margaret" last="Soucheray">Margaret Soucheray</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Miorin, Lisa" sort="Miorin, Lisa" uniqKey="Miorin L" first="Lisa" last="Miorin">Lisa Miorin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029</wicri:regionArea><wicri:noRegion>10029</wicri:noRegion></affiliation></author><author><name sortKey="Moreno, Elena" sort="Moreno, Elena" uniqKey="Moreno E" first="Elena" last="Moreno">Elena Moreno</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029</wicri:regionArea><wicri:noRegion>10029</wicri:noRegion></affiliation></author><author><name sortKey="Koh, Cassandra" sort="Koh, Cassandra" uniqKey="Koh C" first="Cassandra" last="Koh">Cassandra Koh</name><affiliation wicri:level="1"><nlm:affiliation>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15</wicri:regionArea><wicri:noRegion>Cedex 15</wicri:noRegion><wicri:noRegion>Cedex 15</wicri:noRegion></affiliation></author><author><name sortKey="Tran, Quang Dinh" sort="Tran, Quang Dinh" uniqKey="Tran Q" first="Quang Dinh" last="Tran">Quang Dinh Tran</name><affiliation wicri:level="1"><nlm:affiliation>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15</wicri:regionArea><wicri:noRegion>Cedex 15</wicri:noRegion><wicri:noRegion>Cedex 15</wicri:noRegion></affiliation></author><author><name sortKey="Hardy, Alexandra" sort="Hardy, Alexandra" uniqKey="Hardy A" first="Alexandra" last="Hardy">Alexandra Hardy</name><affiliation wicri:level="1"><nlm:affiliation>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15</wicri:regionArea><wicri:noRegion>Cedex 15</wicri:noRegion><wicri:noRegion>Cedex 15</wicri:noRegion></affiliation></author><author><name sortKey="Robinot, Remy" sort="Robinot, Remy" uniqKey="Robinot R" first="Rémy" last="Robinot">Rémy Robinot</name><affiliation wicri:level="3"><nlm:affiliation>Virus & Immunity Unit, Department of Virology, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France; Vaccine Research Institute, 94000 Creteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Virus & Immunity Unit, Department of Virology, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France; Vaccine Research Institute, 94000 Creteil</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Vallet, Thomas" sort="Vallet, Thomas" uniqKey="Vallet T" first="Thomas" last="Vallet">Thomas Vallet</name><affiliation wicri:level="1"><nlm:affiliation>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15</wicri:regionArea><wicri:noRegion>Cedex 15</wicri:noRegion><wicri:noRegion>Cedex 15</wicri:noRegion></affiliation></author><author><name sortKey="Nilsson Payant, Benjamin E" sort="Nilsson Payant, Benjamin E" uniqKey="Nilsson Payant B" first="Benjamin E" last="Nilsson-Payant">Benjamin E. Nilsson-Payant</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Hernandez Armenta, Claudia" sort="Hernandez Armenta, Claudia" uniqKey="Hernandez Armenta C" first="Claudia" last="Hernandez-Armenta">Claudia Hernandez-Armenta</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Dunham, Alistair" sort="Dunham, Alistair" uniqKey="Dunham A" first="Alistair" last="Dunham">Alistair Dunham</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Weigang, Sebastian" sort="Weigang, Sebastian" uniqKey="Weigang S" first="Sebastian" last="Weigang">Sebastian Weigang</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Virology, Medical Center - University of Freiburg, Freiburg 79104, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, Medical Center - University of Freiburg, Freiburg 79104</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Knerr, Julian" sort="Knerr, Julian" uniqKey="Knerr J" first="Julian" last="Knerr">Julian Knerr</name><affiliation wicri:level="3"><nlm:affiliation>Institute for Clinical and Experimental Pharmacology and Toxicology, University of Freiburg, Freiburg 79104, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Clinical and Experimental Pharmacology and Toxicology, University of Freiburg, Freiburg 79104</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Modak, Maya" sort="Modak, Maya" uniqKey="Modak M" first="Maya" last="Modak">Maya Modak</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Quintero, Diego" sort="Quintero, Diego" uniqKey="Quintero D" first="Diego" last="Quintero">Diego Quintero</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Zhou, Yuan" sort="Zhou, Yuan" uniqKey="Zhou Y" first="Yuan" last="Zhou">Yuan Zhou</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Dugourd, Aurelien" sort="Dugourd, Aurelien" uniqKey="Dugourd A" first="Aurelien" last="Dugourd">Aurelien Dugourd</name><affiliation wicri:level="3"><nlm:affiliation>Institute for Computational Biomedicine, Bioquant, Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Heidelberg 69120, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Computational Biomedicine, Bioquant, Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Heidelberg 69120</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Valdeolivas, Alberto" sort="Valdeolivas, Alberto" uniqKey="Valdeolivas A" first="Alberto" last="Valdeolivas">Alberto Valdeolivas</name><affiliation wicri:level="3"><nlm:affiliation>Institute for Computational Biomedicine, Bioquant, Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Heidelberg 69120, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Computational Biomedicine, Bioquant, Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Heidelberg 69120</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Patil, Trupti" sort="Patil, Trupti" uniqKey="Patil T" first="Trupti" last="Patil">Trupti Patil</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Li, Qiongyu" sort="Li, Qiongyu" uniqKey="Li Q" first="Qiongyu" last="Li">Qiongyu Li</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Huttenhain, Ruth" sort="Huttenhain, Ruth" uniqKey="Huttenhain R" first="Ruth" last="Hüttenhain">Ruth Hüttenhain</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Cakir, Merve" sort="Cakir, Merve" uniqKey="Cakir M" first="Merve" last="Cakir">Merve Cakir</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Muralidharan, Monita" sort="Muralidharan, Monita" uniqKey="Muralidharan M" first="Monita" last="Muralidharan">Monita Muralidharan</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Kim, Minkyu" sort="Kim, Minkyu" uniqKey="Kim M" first="Minkyu" last="Kim">Minkyu Kim</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Jang, Gwendolyn" sort="Jang, Gwendolyn" uniqKey="Jang G" first="Gwendolyn" last="Jang">Gwendolyn Jang</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Tutuncuoglu, Beril" sort="Tutuncuoglu, Beril" uniqKey="Tutuncuoglu B" first="Beril" last="Tutuncuoglu">Beril Tutuncuoglu</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hiatt, Joseph" sort="Hiatt, Joseph" uniqKey="Hiatt J" first="Joseph" last="Hiatt">Joseph Hiatt</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Guo, Jeffrey Z" sort="Guo, Jeffrey Z" uniqKey="Guo J" first="Jeffrey Z" last="Guo">Jeffrey Z. Guo</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Xu, Jiewei" sort="Xu, Jiewei" uniqKey="Xu J" first="Jiewei" last="Xu">Jiewei Xu</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Bouhaddou, Sophia" sort="Bouhaddou, Sophia" uniqKey="Bouhaddou S" first="Sophia" last="Bouhaddou">Sophia Bouhaddou</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Mathy, Christopher J P" sort="Mathy, Christopher J P" uniqKey="Mathy C" first="Christopher J P" last="Mathy">Christopher J P. Mathy</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Gaulton, Anna" sort="Gaulton, Anna" uniqKey="Gaulton A" first="Anna" last="Gaulton">Anna Gaulton</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Manners, Emma J" sort="Manners, Emma J" uniqKey="Manners E" first="Emma J" last="Manners">Emma J. Manners</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Felix, Eloy" sort="Felix, Eloy" uniqKey="Felix E" first="Eloy" last="Félix">Eloy Félix</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Shi, Ying" sort="Shi, Ying" uniqKey="Shi Y" first="Ying" last="Shi">Ying Shi</name><affiliation><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute.</nlm:affiliation><wicri:noCountry code="subField">USA; Howard Hughes Medical Institute</wicri:noCountry></affiliation></author><author><name sortKey="Goff, Marisa" sort="Goff, Marisa" uniqKey="Goff M" first="Marisa" last="Goff">Marisa Goff</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Lim, Jean K" sort="Lim, Jean K" uniqKey="Lim J" first="Jean K" last="Lim">Jean K. Lim</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Mcbride, Timothy" sort="Mcbride, Timothy" uniqKey="Mcbride T" first="Timothy" last="Mcbride">Timothy Mcbride</name><affiliation wicri:level="2"><nlm:affiliation>Zoic Labs, Culver City, CA 90232, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Zoic Labs, Culver City, CA 90232</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="O Neal, Michael C" sort="O Neal, Michael C" uniqKey="O Neal M" first="Michael C" last="O'Neal">Michael C. O'Neal</name><affiliation wicri:level="2"><nlm:affiliation>Zoic Labs, Culver City, CA 90232, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Zoic Labs, Culver City, CA 90232</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Cai, Yiming" sort="Cai, Yiming" uniqKey="Cai Y" first="Yiming" last="Cai">Yiming Cai</name><affiliation wicri:level="2"><nlm:affiliation>Zoic Labs, Culver City, CA 90232, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Zoic Labs, Culver City, CA 90232</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Chang, Jason C J" sort="Chang, Jason C J" uniqKey="Chang J" first="Jason C J" last="Chang">Jason C J. Chang</name><affiliation wicri:level="2"><nlm:affiliation>Zoic Labs, Culver City, CA 90232, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Zoic Labs, Culver City, CA 90232</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Broadhurst, David J" sort="Broadhurst, David J" uniqKey="Broadhurst D" first="David J" last="Broadhurst">David J. Broadhurst</name><affiliation wicri:level="2"><nlm:affiliation>Zoic Labs, Culver City, CA 90232, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Zoic Labs, Culver City, CA 90232</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Klippsten, Saker" sort="Klippsten, Saker" uniqKey="Klippsten S" first="Saker" last="Klippsten">Saker Klippsten</name><affiliation wicri:level="2"><nlm:affiliation>Zoic Labs, Culver City, CA 90232, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Zoic Labs, Culver City, CA 90232</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="De Wit, Emmie" sort="De Wit, Emmie" uniqKey="De Wit E" first="Emmie" last="De Wit">Emmie De Wit</name><affiliation wicri:level="2"><nlm:affiliation>NIH/NIAID/Rocky Mountain Laboratories, Hamilton, MT 59840, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>NIH/NIAID/Rocky Mountain Laboratories, Hamilton, MT 59840</wicri:regionArea><placeName><region type="state">Montana</region></placeName></affiliation></author><author><name sortKey="Leach, Andrew R" sort="Leach, Andrew R" uniqKey="Leach A" first="Andrew R" last="Leach">Andrew R. Leach</name><affiliation wicri:level="1"><nlm:affiliation>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Kortemme, Tanja" sort="Kortemme, Tanja" uniqKey="Kortemme T" first="Tanja" last="Kortemme">Tanja Kortemme</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Shoichet, Brian" sort="Shoichet, Brian" uniqKey="Shoichet B" first="Brian" last="Shoichet">Brian Shoichet</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Ott, Melanie" sort="Ott, Melanie" uniqKey="Ott M" first="Melanie" last="Ott">Melanie Ott</name><affiliation wicri:level="2"><nlm:affiliation>J. David Gladstone Institutes, San Francisco, CA 94158, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>J. David Gladstone Institutes, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Saez Rodriguez, Julio" sort="Saez Rodriguez, Julio" uniqKey="Saez Rodriguez J" first="Julio" last="Saez-Rodriguez">Julio Saez-Rodriguez</name><affiliation wicri:level="3"><nlm:affiliation>Institute for Computational Biomedicine, Bioquant, Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Heidelberg 69120, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Computational Biomedicine, Bioquant, Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Heidelberg 69120</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Tenoever, Benjamin R" sort="Tenoever, Benjamin R" uniqKey="Tenoever B" first="Benjamin R" last="Tenoever">Benjamin R. Tenoever</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Mullins, R Dyche" sort="Mullins, R Dyche" uniqKey="Mullins R" first="R Dyche" last="Mullins">R Dyche Mullins</name><affiliation><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute.</nlm:affiliation><wicri:noCountry code="subField">USA; Howard Hughes Medical Institute</wicri:noCountry></affiliation></author><author><name sortKey="Fischer, Elizabeth R" sort="Fischer, Elizabeth R" uniqKey="Fischer E" first="Elizabeth R" last="Fischer">Elizabeth R. Fischer</name><affiliation wicri:level="2"><nlm:affiliation>NIH/NIAID/Rocky Mountain Laboratories, Hamilton, MT 59840, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>NIH/NIAID/Rocky Mountain Laboratories, Hamilton, MT 59840</wicri:regionArea><placeName><region type="state">Montana</region></placeName></affiliation></author><author><name sortKey="Kochs, Georg" sort="Kochs, Georg" uniqKey="Kochs G" first="Georg" last="Kochs">Georg Kochs</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Virology, Medical Center - University of Freiburg, Freiburg 79104, Germany; Faculty of Medicine, University of Freiburg, Freiburg 79008, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, Medical Center - University of Freiburg, Freiburg 79104, Germany; Faculty of Medicine, University of Freiburg, Freiburg 79008</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Grosse, Robert" sort="Grosse, Robert" uniqKey="Grosse R" first="Robert" last="Grosse">Robert Grosse</name><affiliation wicri:level="3"><nlm:affiliation>Institute for Clinical and Experimental Pharmacology and Toxicology, University of Freiburg, Freiburg 79104, Germany; Faculty of Medicine, University of Freiburg, Freiburg 79008, Germany; Centre for Integrative Biological Signalling Studies (CIBSS), Freiburg 79104, Germany. Electronic address: robert.grosse@pharmakol.uni-freiburg.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Clinical and Experimental Pharmacology and Toxicology, University of Freiburg, Freiburg 79104, Germany; Faculty of Medicine, University of Freiburg, Freiburg 79008, Germany; Centre for Integrative Biological Signalling Studies (CIBSS), Freiburg 79104</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="García-Sastre">Adolfo García-Sastre</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. Electronic address: adolfo.garcia-sastre@mssm.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029</wicri:regionArea><wicri:noRegion>10029</wicri:noRegion></affiliation></author><author><name sortKey="Vignuzzi, Marco" sort="Vignuzzi, Marco" uniqKey="Vignuzzi M" first="Marco" last="Vignuzzi">Marco Vignuzzi</name><affiliation wicri:level="1"><nlm:affiliation>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France. Electronic address: marco.vignuzzi@pasteur.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15</wicri:regionArea><wicri:noRegion>Cedex 15</wicri:noRegion><wicri:noRegion>Cedex 15</wicri:noRegion></affiliation></author><author><name sortKey="Johnson, Jeffery R" sort="Johnson, Jeffery R" uniqKey="Johnson J" first="Jeffery R" last="Johnson">Jeffery R. Johnson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: jeffrey.johnson@mssm.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Shokat, Kevan M" sort="Shokat, Kevan M" uniqKey="Shokat K" first="Kevan M" last="Shokat">Kevan M. Shokat</name><affiliation wicri:level="1"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute. Electronic address: kevan.shokat@ucsf.edu.</nlm:affiliation><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Swaney, Danielle L" sort="Swaney, Danielle L" uniqKey="Swaney D" first="Danielle L" last="Swaney">Danielle L. Swaney</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: danielle.swaney@ucsf.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Beltrao, Pedro" sort="Beltrao, Pedro" uniqKey="Beltrao P" first="Pedro" last="Beltrao">Pedro Beltrao</name><affiliation wicri:level="1"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK. Electronic address: pbeltrao@ebi.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Krogan, Nevan J" sort="Krogan, Nevan J" uniqKey="Krogan N" first="Nevan J" last="Krogan">Nevan J. Krogan</name><affiliation wicri:level="2"><nlm:affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: nevan.krogan@ucsf.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j">Cell</title><idno type="eISSN">1097-4172</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>A549 Cells (MeSH)</term><term>Animals (MeSH)</term><term>Antiviral Agents (pharmacology)</term><term>Betacoronavirus (metabolism)</term><term>Caco-2 Cells (MeSH)</term><term>Casein Kinase II (antagonists & inhibitors)</term><term>Casein Kinase II (metabolism)</term><term>Chlorocebus aethiops (MeSH)</term><term>Coronavirus Infections (metabolism)</term><term>Coronavirus Infections (virology)</term><term>Cyclin-Dependent Kinases (antagonists & inhibitors)</term><term>Cyclin-Dependent Kinases (metabolism)</term><term>Drug Evaluation, Preclinical (methods)</term><term>HEK293 Cells (MeSH)</term><term>Host-Pathogen Interactions (MeSH)</term><term>Humans (MeSH)</term><term>Pandemics (MeSH)</term><term>Peptidyl-Dipeptidase A (genetics)</term><term>Peptidyl-Dipeptidase A (metabolism)</term><term>Phosphatidylinositol 3-Kinases (metabolism)</term><term>Phosphoinositide-3 Kinase Inhibitors (pharmacology)</term><term>Phosphorylation (MeSH)</term><term>Pneumonia, Viral (metabolism)</term><term>Pneumonia, Viral (virology)</term><term>Protein Kinase Inhibitors (pharmacology)</term><term>Proteomics (methods)</term><term>Proto-Oncogene Proteins (antagonists & inhibitors)</term><term>Proto-Oncogene Proteins (metabolism)</term><term>Receptor Protein-Tyrosine Kinases (antagonists & inhibitors)</term><term>Receptor Protein-Tyrosine Kinases (metabolism)</term><term>Spike Glycoprotein, Coronavirus (metabolism)</term><term>Vero Cells (MeSH)</term><term>p38 Mitogen-Activated Protein Kinases (antagonists & inhibitors)</term><term>p38 Mitogen-Activated Protein Kinases (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Antiviraux (pharmacologie)</term><term>Betacoronavirus (métabolisme)</term><term>Casein Kinase II (antagonistes et inhibiteurs)</term><term>Casein Kinase II (métabolisme)</term><term>Cellules A549 (MeSH)</term><term>Cellules Caco-2 (MeSH)</term><term>Cellules HEK293 (MeSH)</term><term>Cellules Vero (MeSH)</term><term>Glycoprotéine de spicule des coronavirus (métabolisme)</term><term>Humains (MeSH)</term><term>Infections à coronavirus (métabolisme)</term><term>Infections à coronavirus (virologie)</term><term>Inhibiteurs de protéines kinases (pharmacologie)</term><term>Interactions hôte-pathogène (MeSH)</term><term>Kinases cyclines-dépendantes (antagonistes et inhibiteurs)</term><term>Kinases cyclines-dépendantes (métabolisme)</term><term>Pandémies (MeSH)</term><term>Peptidyl-Dipeptidase A (génétique)</term><term>Peptidyl-Dipeptidase A (métabolisme)</term><term>Phosphatidylinositol 3-kinases (métabolisme)</term><term>Phosphorylation (MeSH)</term><term>Pneumopathie virale (métabolisme)</term><term>Pneumopathie virale (virologie)</term><term>Protéines proto-oncogènes (antagonistes et inhibiteurs)</term><term>Protéines proto-oncogènes (métabolisme)</term><term>Protéomique (méthodes)</term><term>Récepteurs à activité tyrosine kinase (antagonistes et inhibiteurs)</term><term>Récepteurs à activité tyrosine kinase (métabolisme)</term><term>p38 Mitogen-Activated Protein Kinases (antagonistes et inhibiteurs)</term><term>p38 Mitogen-Activated Protein Kinases (métabolisme)</term><term>Évaluation préclinique de médicament (méthodes)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Casein Kinase II</term><term>Cyclin-Dependent Kinases</term><term>Proto-Oncogene Proteins</term><term>Receptor Protein-Tyrosine Kinases</term><term>p38 Mitogen-Activated Protein Kinases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Peptidyl-Dipeptidase A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Casein Kinase II</term><term>Cyclin-Dependent Kinases</term><term>Peptidyl-Dipeptidase A</term><term>Proto-Oncogene Proteins</term><term>Receptor Protein-Tyrosine Kinases</term><term>Spike Glycoprotein, Coronavirus</term><term>p38 Mitogen-Activated Protein Kinases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Phosphoinositide-3 Kinase Inhibitors</term><term>Protein Kinase Inhibitors</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Casein Kinase II</term><term>Kinases cyclines-dépendantes</term><term>Protéines proto-oncogènes</term><term>Récepteurs à activité tyrosine kinase</term><term>p38 Mitogen-Activated Protein Kinases</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Peptidyl-Dipeptidase A</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Betacoronavirus</term><term>Coronavirus Infections</term><term>Phosphatidylinositol 3-Kinases</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Drug Evaluation, Preclinical</term><term>Proteomics</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Betacoronavirus</term><term>Casein Kinase II</term><term>Glycoprotéine de spicule des coronavirus</term><term>Infections à coronavirus</term><term>Kinases cyclines-dépendantes</term><term>Peptidyl-Dipeptidase A</term><term>Phosphatidylinositol 3-kinases</term><term>Pneumopathie virale</term><term>Protéines proto-oncogènes</term><term>Récepteurs à activité tyrosine kinase</term><term>p38 Mitogen-Activated Protein Kinases</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Protéomique</term><term>Évaluation préclinique de médicament</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Inhibiteurs de protéines kinases</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>A549 Cells</term><term>Animals</term><term>Caco-2 Cells</term><term>Chlorocebus aethiops</term><term>HEK293 Cells</term><term>Host-Pathogen Interactions</term><term>Humans</term><term>Pandemics</term><term>Phosphorylation</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules A549</term><term>Cellules Caco-2</term><term>Cellules HEK293</term><term>Cellules Vero</term><term>Humains</term><term>Interactions hôte-pathogène</term><term>Pandémies</term><term>Phosphorylation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed hundreds of thousands of people worldwide, highlighting an urgent need to develop antiviral therapies. Here we present a quantitative mass spectrometry-based phosphoproteomics survey of SARS-CoV-2 infection in Vero E6 cells, revealing dramatic rewiring of phosphorylation on host and viral proteins. SARS-CoV-2 infection promoted casein kinase II (CK2) and p38 MAPK activation, production of diverse cytokines, and shutdown of mitotic kinases, resulting in cell cycle arrest. Infection also stimulated a marked induction of CK2-containing filopodial protrusions possessing budding viral particles. Eighty-seven drugs and compounds were identified by mapping global phosphorylation profiles to dysregulated kinases and pathways. We found pharmacologic inhibition of the p38, CK2, CDK, AXL, and PIKFYVE kinases to possess antiviral efficacy, representing potential COVID-19 therapies.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32645325</PMID><DateCompleted><Year>2020</Year><Month>08</Month><Day>28</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>24</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1097-4172</ISSN><JournalIssue CitedMedium="Internet"><Volume>182</Volume><Issue>3</Issue><PubDate><Year>2020</Year><Month>08</Month><Day>06</Day></PubDate></JournalIssue><Title>Cell</Title><ISOAbbreviation>Cell</ISOAbbreviation></Journal><ArticleTitle>The Global Phosphorylation Landscape of SARS-CoV-2 Infection.</ArticleTitle><Pagination><MedlinePgn>685-712.e19</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0092-8674(20)30811-4</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cell.2020.06.034</ELocationID><Abstract><AbstractText>The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed hundreds of thousands of people worldwide, highlighting an urgent need to develop antiviral therapies. Here we present a quantitative mass spectrometry-based phosphoproteomics survey of SARS-CoV-2 infection in Vero E6 cells, revealing dramatic rewiring of phosphorylation on host and viral proteins. SARS-CoV-2 infection promoted casein kinase II (CK2) and p38 MAPK activation, production of diverse cytokines, and shutdown of mitotic kinases, resulting in cell cycle arrest. Infection also stimulated a marked induction of CK2-containing filopodial protrusions possessing budding viral particles. Eighty-seven drugs and compounds were identified by mapping global phosphorylation profiles to dysregulated kinases and pathways. We found pharmacologic inhibition of the p38, CK2, CDK, AXL, and PIKFYVE kinases to possess antiviral efficacy, representing potential COVID-19 therapies.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bouhaddou</LastName><ForeName>Mehdi</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Memon</LastName><ForeName>Danish</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meyer</LastName><ForeName>Bjoern</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>White</LastName><ForeName>Kris M</ForeName><Initials>KM</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rezelj</LastName><ForeName>Veronica V</ForeName><Initials>VV</Initials><AffiliationInfo><Affiliation>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Correa Marrero</LastName><ForeName>Miguel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Polacco</LastName><ForeName>Benjamin J</ForeName><Initials>BJ</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Melnyk</LastName><ForeName>James E</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ulferts</LastName><ForeName>Svenja</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute for Clinical and Experimental Pharmacology and Toxicology, University of Freiburg, Freiburg 79104, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kaake</LastName><ForeName>Robyn M</ForeName><Initials>RM</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Batra</LastName><ForeName>Jyoti</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Richards</LastName><ForeName>Alicia L</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stevenson</LastName><ForeName>Erica</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gordon</LastName><ForeName>David E</ForeName><Initials>DE</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rojc</LastName><ForeName>Ajda</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Obernier</LastName><ForeName>Kirsten</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fabius</LastName><ForeName>Jacqueline M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Soucheray</LastName><ForeName>Margaret</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miorin</LastName><ForeName>Lisa</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moreno</LastName><ForeName>Elena</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Koh</LastName><ForeName>Cassandra</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tran</LastName><ForeName>Quang Dinh</ForeName><Initials>QD</Initials><AffiliationInfo><Affiliation>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hardy</LastName><ForeName>Alexandra</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Robinot</LastName><ForeName>Rémy</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Virus & Immunity Unit, Department of Virology, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France; Vaccine Research Institute, 94000 Creteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vallet</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nilsson-Payant</LastName><ForeName>Benjamin E</ForeName><Initials>BE</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hernandez-Armenta</LastName><ForeName>Claudia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dunham</LastName><ForeName>Alistair</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weigang</LastName><ForeName>Sebastian</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Virology, Medical Center - University of Freiburg, Freiburg 79104, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Knerr</LastName><ForeName>Julian</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute for Clinical and Experimental Pharmacology and Toxicology, University of Freiburg, Freiburg 79104, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Modak</LastName><ForeName>Maya</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quintero</LastName><ForeName>Diego</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Yuan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dugourd</LastName><ForeName>Aurelien</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute for Computational Biomedicine, Bioquant, Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Heidelberg 69120, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Valdeolivas</LastName><ForeName>Alberto</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute for Computational Biomedicine, Bioquant, Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Heidelberg 69120, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Patil</LastName><ForeName>Trupti</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Qiongyu</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hüttenhain</LastName><ForeName>Ruth</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cakir</LastName><ForeName>Merve</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Muralidharan</LastName><ForeName>Monita</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Minkyu</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jang</LastName><ForeName>Gwendolyn</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tutuncuoglu</LastName><ForeName>Beril</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hiatt</LastName><ForeName>Joseph</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guo</LastName><ForeName>Jeffrey Z</ForeName><Initials>JZ</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Jiewei</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bouhaddou</LastName><ForeName>Sophia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mathy</LastName><ForeName>Christopher J P</ForeName><Initials>CJP</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gaulton</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manners</LastName><ForeName>Emma J</ForeName><Initials>EJ</Initials><AffiliationInfo><Affiliation>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Félix</LastName><ForeName>Eloy</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shi</LastName><ForeName>Ying</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goff</LastName><ForeName>Marisa</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lim</LastName><ForeName>Jean K</ForeName><Initials>JK</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McBride</LastName><ForeName>Timothy</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Zoic Labs, Culver City, CA 90232, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Neal</LastName><ForeName>Michael C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Zoic Labs, Culver City, CA 90232, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cai</LastName><ForeName>Yiming</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Zoic Labs, Culver City, CA 90232, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chang</LastName><ForeName>Jason C J</ForeName><Initials>JCJ</Initials><AffiliationInfo><Affiliation>Zoic Labs, Culver City, CA 90232, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Broadhurst</LastName><ForeName>David J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Zoic Labs, Culver City, CA 90232, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Klippsten</LastName><ForeName>Saker</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Zoic Labs, Culver City, CA 90232, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Wit</LastName><ForeName>Emmie</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>NIH/NIAID/Rocky Mountain Laboratories, Hamilton, MT 59840, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leach</LastName><ForeName>Andrew R</ForeName><Initials>AR</Initials><AffiliationInfo><Affiliation>European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kortemme</LastName><ForeName>Tanja</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shoichet</LastName><ForeName>Brian</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ott</LastName><ForeName>Melanie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>J. David Gladstone Institutes, San Francisco, CA 94158, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saez-Rodriguez</LastName><ForeName>Julio</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute for Computational Biomedicine, Bioquant, Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Heidelberg 69120, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>tenOever</LastName><ForeName>Benjamin R</ForeName><Initials>BR</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mullins</LastName><ForeName>R Dyche</ForeName><Initials>RD</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fischer</LastName><ForeName>Elizabeth R</ForeName><Initials>ER</Initials><AffiliationInfo><Affiliation>NIH/NIAID/Rocky Mountain Laboratories, Hamilton, MT 59840, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kochs</LastName><ForeName>Georg</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Institute of Virology, Medical Center - University of Freiburg, Freiburg 79104, Germany; Faculty of Medicine, University of Freiburg, Freiburg 79008, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grosse</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Institute for Clinical and Experimental Pharmacology and Toxicology, University of Freiburg, Freiburg 79104, Germany; Faculty of Medicine, University of Freiburg, Freiburg 79008, Germany; Centre for Integrative Biological Signalling Studies (CIBSS), Freiburg 79104, Germany. Electronic address: robert.grosse@pharmakol.uni-freiburg.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>García-Sastre</LastName><ForeName>Adolfo</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. Electronic address: adolfo.garcia-sastre@mssm.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vignuzzi</LastName><ForeName>Marco</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France. Electronic address: marco.vignuzzi@pasteur.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Johnson</LastName><ForeName>Jeffery R</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: jeffrey.johnson@mssm.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shokat</LastName><ForeName>Kevan M</ForeName><Initials>KM</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute. Electronic address: kevan.shokat@ucsf.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Swaney</LastName><ForeName>Danielle L</ForeName><Initials>DL</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: danielle.swaney@ucsf.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beltrao</LastName><ForeName>Pedro</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK. Electronic address: pbeltrao@ebi.ac.uk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krogan</LastName><ForeName>Nevan J</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: nevan.krogan@ucsf.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>HHSN272201400008C</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AI120694</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U19 AI135990</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AI122747</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>F32 CA239333</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA221969</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA244550</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 GM133981</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U19 AI118610</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U19 AI135972</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P50 AI150476</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AI143292</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>F32 CA236347</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><Acronym>ERC_</Acronym><Agency>European Research Council</Agency><Country>International</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>06</Month><Day>28</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cell</MedlineTA><NlmUniqueID>0413066</NlmUniqueID><ISSNLinking>0092-8674</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000081082">Phosphoinositide-3 Kinase Inhibitors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D047428">Protein Kinase Inhibitors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011518">Proto-Oncogene Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D064370">Spike Glycoprotein, Coronavirus</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C000657845">spike protein, SARS-CoV-2</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.137</RegistryNumber><NameOfSubstance UI="C492139">PIKFYVE protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.10.1</RegistryNumber><NameOfSubstance UI="D020794">Receptor Protein-Tyrosine Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.10.1</RegistryNumber><NameOfSubstance UI="C071031">axl receptor tyrosine kinase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="D047390">Casein Kinase II</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.22</RegistryNumber><NameOfSubstance UI="D018844">Cyclin-Dependent Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.24</RegistryNumber><NameOfSubstance UI="D048051">p38 Mitogen-Activated Protein Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.15.1</RegistryNumber><NameOfSubstance UI="D007703">Peptidyl-Dipeptidase A</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.17.-</RegistryNumber><NameOfSubstance UI="C413524">angiotensin converting enzyme 2</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000072283" MajorTopicYN="N">A549 Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018938" MajorTopicYN="N">Caco-2 Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D047390" MajorTopicYN="N">Casein Kinase II</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002522" MajorTopicYN="N">Chlorocebus aethiops</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018844" MajorTopicYN="N">Cyclin-Dependent Kinases</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004353" MajorTopicYN="N">Drug Evaluation, Preclinical</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D057809" MajorTopicYN="N">HEK293 Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D054884" MajorTopicYN="N">Host-Pathogen Interactions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007703" MajorTopicYN="N">Peptidyl-Dipeptidase A</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019869" MajorTopicYN="N">Phosphatidylinositol 3-Kinases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000081082" MajorTopicYN="N">Phosphoinositide-3 Kinase Inhibitors</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010766" MajorTopicYN="N">Phosphorylation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D047428" MajorTopicYN="N">Protein Kinase Inhibitors</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D040901" MajorTopicYN="N">Proteomics</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011518" MajorTopicYN="N">Proto-Oncogene Proteins</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020794" MajorTopicYN="N">Receptor Protein-Tyrosine Kinases</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D064370" MajorTopicYN="N">Spike Glycoprotein, Coronavirus</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014709" MajorTopicYN="N">Vero Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D048051" MajorTopicYN="N">p38 Mitogen-Activated Protein Kinases</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">AXL</Keyword><Keyword MajorTopicYN="Y">CDK</Keyword><Keyword MajorTopicYN="Y">MAPK</Keyword><Keyword MajorTopicYN="Y">PIKFYVE</Keyword><Keyword MajorTopicYN="Y">SARS-CoV-2</Keyword><Keyword MajorTopicYN="Y">antiviral</Keyword><Keyword MajorTopicYN="Y">casein kinase II</Keyword><Keyword MajorTopicYN="Y">mass spectrometry</Keyword><Keyword MajorTopicYN="Y">p38</Keyword><Keyword MajorTopicYN="Y">phosphoproteomics</Keyword></KeywordList><CoiStatement>Declaration of Interests The Krogan laboratory has received research support from Vir Biotechnology and F. Hoffmann-La Roche. K.M.S. has consulting agreements for the following companies involving cash and/or stock compensation: Black Diamond Therapeutics, BridGene Biosciences, Denali Therapeutics, Dice Molecules, eFFECTOR Therapeutics (zotatifin and tomivosertib), Erasca, Genentech/Roche, Janssen Pharmaceuticals, Kumquat Biosciences, Kura Oncology, Merck, Mitokinin, Petra Pharma, Qulab Inc. Revolution Medicines (WDB002), Type6 Therapeutics, Venthera, and Wellspring Biosciences (Araxes Pharma).</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>06</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>06</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>7</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32645325</ArticleId><ArticleId IdType="pii">S0092-8674(20)30811-4</ArticleId><ArticleId IdType="doi">10.1016/j.cell.2020.06.034</ArticleId><ArticleId IdType="pmc">PMC7321036</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>France</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Bade-Wurtemberg</li><li>Californie</li><li>District de Fribourg-en-Brisgau</li><li>District de Karlsruhe</li><li>Montana</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Créteil</li><li>Fribourg-en-Brisgau</li><li>Heidelberg</li></settlement></list><tree><noCountry><name sortKey="Melnyk, James E" sort="Melnyk, James E" uniqKey="Melnyk J" first="James E" last="Melnyk">James E. Melnyk</name><name sortKey="Mullins, R Dyche" sort="Mullins, R Dyche" uniqKey="Mullins R" first="R Dyche" last="Mullins">R Dyche Mullins</name><name sortKey="Shi, Ying" sort="Shi, Ying" uniqKey="Shi Y" first="Ying" last="Shi">Ying Shi</name></noCountry><country name="États-Unis"><region name="Californie"><name sortKey="Bouhaddou, Mehdi" sort="Bouhaddou, Mehdi" uniqKey="Bouhaddou M" first="Mehdi" last="Bouhaddou">Mehdi Bouhaddou</name></region><name sortKey="Batra, Jyoti" sort="Batra, Jyoti" uniqKey="Batra J" first="Jyoti" last="Batra">Jyoti Batra</name><name sortKey="Bouhaddou, Sophia" sort="Bouhaddou, Sophia" uniqKey="Bouhaddou S" first="Sophia" last="Bouhaddou">Sophia Bouhaddou</name><name sortKey="Broadhurst, David J" sort="Broadhurst, David J" uniqKey="Broadhurst D" first="David J" last="Broadhurst">David J. Broadhurst</name><name sortKey="Cai, Yiming" sort="Cai, Yiming" uniqKey="Cai Y" first="Yiming" last="Cai">Yiming Cai</name><name sortKey="Cakir, Merve" sort="Cakir, Merve" uniqKey="Cakir M" first="Merve" last="Cakir">Merve Cakir</name><name sortKey="Chang, Jason C J" sort="Chang, Jason C J" uniqKey="Chang J" first="Jason C J" last="Chang">Jason C J. Chang</name><name sortKey="De Wit, Emmie" sort="De Wit, Emmie" uniqKey="De Wit E" first="Emmie" last="De Wit">Emmie De Wit</name><name sortKey="Fabius, Jacqueline M" sort="Fabius, Jacqueline M" uniqKey="Fabius J" first="Jacqueline M" last="Fabius">Jacqueline M. Fabius</name><name sortKey="Fischer, Elizabeth R" sort="Fischer, Elizabeth R" uniqKey="Fischer E" first="Elizabeth R" last="Fischer">Elizabeth R. Fischer</name><name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="García-Sastre">Adolfo García-Sastre</name><name sortKey="Goff, Marisa" sort="Goff, Marisa" uniqKey="Goff M" first="Marisa" last="Goff">Marisa Goff</name><name sortKey="Gordon, David E" sort="Gordon, David E" uniqKey="Gordon D" first="David E" last="Gordon">David E. Gordon</name><name sortKey="Guo, Jeffrey Z" sort="Guo, Jeffrey Z" uniqKey="Guo J" first="Jeffrey Z" last="Guo">Jeffrey Z. Guo</name><name sortKey="Hiatt, Joseph" sort="Hiatt, Joseph" uniqKey="Hiatt J" first="Joseph" last="Hiatt">Joseph Hiatt</name><name sortKey="Huttenhain, Ruth" sort="Huttenhain, Ruth" uniqKey="Huttenhain R" first="Ruth" last="Hüttenhain">Ruth Hüttenhain</name><name sortKey="Jang, Gwendolyn" sort="Jang, Gwendolyn" uniqKey="Jang G" first="Gwendolyn" last="Jang">Gwendolyn Jang</name><name sortKey="Johnson, Jeffery R" sort="Johnson, Jeffery R" uniqKey="Johnson J" first="Jeffery R" last="Johnson">Jeffery R. Johnson</name><name sortKey="Kaake, Robyn M" sort="Kaake, Robyn M" uniqKey="Kaake R" first="Robyn M" last="Kaake">Robyn M. Kaake</name><name sortKey="Kim, Minkyu" sort="Kim, Minkyu" uniqKey="Kim M" first="Minkyu" last="Kim">Minkyu Kim</name><name sortKey="Klippsten, Saker" sort="Klippsten, Saker" uniqKey="Klippsten S" first="Saker" last="Klippsten">Saker Klippsten</name><name sortKey="Kortemme, Tanja" sort="Kortemme, Tanja" uniqKey="Kortemme T" first="Tanja" last="Kortemme">Tanja Kortemme</name><name sortKey="Krogan, Nevan J" sort="Krogan, Nevan J" uniqKey="Krogan N" first="Nevan J" last="Krogan">Nevan J. Krogan</name><name sortKey="Li, Qiongyu" sort="Li, Qiongyu" uniqKey="Li Q" first="Qiongyu" last="Li">Qiongyu Li</name><name sortKey="Lim, Jean K" sort="Lim, Jean K" uniqKey="Lim J" first="Jean K" last="Lim">Jean K. Lim</name><name sortKey="Mathy, Christopher J P" sort="Mathy, Christopher J P" uniqKey="Mathy C" first="Christopher J P" last="Mathy">Christopher J P. Mathy</name><name sortKey="Mcbride, Timothy" sort="Mcbride, Timothy" uniqKey="Mcbride T" first="Timothy" last="Mcbride">Timothy Mcbride</name><name sortKey="Miorin, Lisa" sort="Miorin, Lisa" uniqKey="Miorin L" first="Lisa" last="Miorin">Lisa Miorin</name><name sortKey="Modak, Maya" sort="Modak, Maya" uniqKey="Modak M" first="Maya" last="Modak">Maya Modak</name><name sortKey="Moreno, Elena" sort="Moreno, Elena" uniqKey="Moreno E" first="Elena" last="Moreno">Elena Moreno</name><name sortKey="Muralidharan, Monita" sort="Muralidharan, Monita" uniqKey="Muralidharan M" first="Monita" last="Muralidharan">Monita Muralidharan</name><name sortKey="Nilsson Payant, Benjamin E" sort="Nilsson Payant, Benjamin E" uniqKey="Nilsson Payant B" first="Benjamin E" last="Nilsson-Payant">Benjamin E. Nilsson-Payant</name><name sortKey="O Neal, Michael C" sort="O Neal, Michael C" uniqKey="O Neal M" first="Michael C" last="O'Neal">Michael C. O'Neal</name><name sortKey="Obernier, Kirsten" sort="Obernier, Kirsten" uniqKey="Obernier K" first="Kirsten" last="Obernier">Kirsten Obernier</name><name sortKey="Ott, Melanie" sort="Ott, Melanie" uniqKey="Ott M" first="Melanie" last="Ott">Melanie Ott</name><name sortKey="Patil, Trupti" sort="Patil, Trupti" uniqKey="Patil T" first="Trupti" last="Patil">Trupti Patil</name><name sortKey="Polacco, Benjamin J" sort="Polacco, Benjamin J" uniqKey="Polacco B" first="Benjamin J" last="Polacco">Benjamin J. Polacco</name><name sortKey="Quintero, Diego" sort="Quintero, Diego" uniqKey="Quintero D" first="Diego" last="Quintero">Diego Quintero</name><name sortKey="Richards, Alicia L" sort="Richards, Alicia L" uniqKey="Richards A" first="Alicia L" last="Richards">Alicia L. Richards</name><name sortKey="Rojc, Ajda" sort="Rojc, Ajda" uniqKey="Rojc A" first="Ajda" last="Rojc">Ajda Rojc</name><name sortKey="Shoichet, Brian" sort="Shoichet, Brian" uniqKey="Shoichet B" first="Brian" last="Shoichet">Brian Shoichet</name><name sortKey="Shokat, Kevan M" sort="Shokat, Kevan M" uniqKey="Shokat K" first="Kevan M" last="Shokat">Kevan M. Shokat</name><name sortKey="Soucheray, Margaret" sort="Soucheray, Margaret" uniqKey="Soucheray M" first="Margaret" last="Soucheray">Margaret Soucheray</name><name sortKey="Stevenson, Erica" sort="Stevenson, Erica" uniqKey="Stevenson E" first="Erica" last="Stevenson">Erica Stevenson</name><name sortKey="Swaney, Danielle L" sort="Swaney, Danielle L" uniqKey="Swaney D" first="Danielle L" last="Swaney">Danielle L. Swaney</name><name sortKey="Tenoever, Benjamin R" sort="Tenoever, Benjamin R" uniqKey="Tenoever B" first="Benjamin R" last="Tenoever">Benjamin R. Tenoever</name><name sortKey="Tutuncuoglu, Beril" sort="Tutuncuoglu, Beril" uniqKey="Tutuncuoglu B" first="Beril" last="Tutuncuoglu">Beril Tutuncuoglu</name><name sortKey="White, Kris M" sort="White, Kris M" uniqKey="White K" first="Kris M" last="White">Kris M. White</name><name sortKey="Xu, Jiewei" sort="Xu, Jiewei" uniqKey="Xu J" first="Jiewei" last="Xu">Jiewei Xu</name><name sortKey="Zhou, Yuan" sort="Zhou, Yuan" uniqKey="Zhou Y" first="Yuan" last="Zhou">Yuan Zhou</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Memon, Danish" sort="Memon, Danish" uniqKey="Memon D" first="Danish" last="Memon">Danish Memon</name></noRegion><name sortKey="Beltrao, Pedro" sort="Beltrao, Pedro" uniqKey="Beltrao P" first="Pedro" last="Beltrao">Pedro Beltrao</name><name sortKey="Correa Marrero, Miguel" sort="Correa Marrero, Miguel" uniqKey="Correa Marrero M" first="Miguel" last="Correa Marrero">Miguel Correa Marrero</name><name sortKey="Dunham, Alistair" sort="Dunham, Alistair" uniqKey="Dunham A" first="Alistair" last="Dunham">Alistair Dunham</name><name sortKey="Felix, Eloy" sort="Felix, Eloy" uniqKey="Felix E" first="Eloy" last="Félix">Eloy Félix</name><name sortKey="Gaulton, Anna" sort="Gaulton, Anna" uniqKey="Gaulton A" first="Anna" last="Gaulton">Anna Gaulton</name><name sortKey="Hernandez Armenta, Claudia" sort="Hernandez Armenta, Claudia" uniqKey="Hernandez Armenta C" first="Claudia" last="Hernandez-Armenta">Claudia Hernandez-Armenta</name><name sortKey="Leach, Andrew R" sort="Leach, Andrew R" uniqKey="Leach A" first="Andrew R" last="Leach">Andrew R. Leach</name><name sortKey="Manners, Emma J" sort="Manners, Emma J" uniqKey="Manners E" first="Emma J" last="Manners">Emma J. Manners</name></country><country name="France"><noRegion><name sortKey="Meyer, Bjoern" sort="Meyer, Bjoern" uniqKey="Meyer B" first="Bjoern" last="Meyer">Bjoern Meyer</name></noRegion><name sortKey="Hardy, Alexandra" sort="Hardy, Alexandra" uniqKey="Hardy A" first="Alexandra" last="Hardy">Alexandra Hardy</name><name sortKey="Koh, Cassandra" sort="Koh, Cassandra" uniqKey="Koh C" first="Cassandra" last="Koh">Cassandra Koh</name><name sortKey="Rezelj, Veronica V" sort="Rezelj, Veronica V" uniqKey="Rezelj V" first="Veronica V" last="Rezelj">Veronica V. Rezelj</name><name sortKey="Robinot, Remy" sort="Robinot, Remy" uniqKey="Robinot R" first="Rémy" last="Robinot">Rémy Robinot</name><name sortKey="Tran, Quang Dinh" sort="Tran, Quang Dinh" uniqKey="Tran Q" first="Quang Dinh" last="Tran">Quang Dinh Tran</name><name sortKey="Vallet, Thomas" sort="Vallet, Thomas" uniqKey="Vallet T" first="Thomas" last="Vallet">Thomas Vallet</name><name sortKey="Vignuzzi, Marco" sort="Vignuzzi, Marco" uniqKey="Vignuzzi M" first="Marco" last="Vignuzzi">Marco Vignuzzi</name></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Ulferts, Svenja" sort="Ulferts, Svenja" uniqKey="Ulferts S" first="Svenja" last="Ulferts">Svenja Ulferts</name></region><name sortKey="Dugourd, Aurelien" sort="Dugourd, Aurelien" uniqKey="Dugourd A" first="Aurelien" last="Dugourd">Aurelien Dugourd</name><name sortKey="Grosse, Robert" sort="Grosse, Robert" uniqKey="Grosse R" first="Robert" last="Grosse">Robert Grosse</name><name sortKey="Knerr, Julian" sort="Knerr, Julian" uniqKey="Knerr J" first="Julian" last="Knerr">Julian Knerr</name><name sortKey="Kochs, Georg" sort="Kochs, Georg" uniqKey="Kochs G" first="Georg" last="Kochs">Georg Kochs</name><name sortKey="Saez Rodriguez, Julio" sort="Saez Rodriguez, Julio" uniqKey="Saez Rodriguez J" first="Julio" last="Saez-Rodriguez">Julio Saez-Rodriguez</name><name sortKey="Valdeolivas, Alberto" sort="Valdeolivas, Alberto" uniqKey="Valdeolivas A" first="Alberto" last="Valdeolivas">Alberto Valdeolivas</name><name sortKey="Weigang, Sebastian" sort="Weigang, Sebastian" uniqKey="Weigang S" first="Sebastian" last="Weigang">Sebastian Weigang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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